The novel Arrowsmith by Sinclair Lewis tells the story of a young doctor named Martin Arrowsmith who is determined to find a cure for the plague. He travels to the remote island of St. Croix to study the disease and eventually discovers a serum that can save lives. However, his work is opposed by the medical establishment and he is forced to flee the country. Despite these setbacks, Arrowsmith remains dedicated to his work and eventually finds success.